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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN11
All Species:
26.67
Human Site:
S539
Identified Species:
58.67
UniProt:
Q06124
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06124
NP_002825.3
597
68436
S539
R
I
E
E
E
Q
K
S
K
R
K
G
H
E
Y
Chimpanzee
Pan troglodytes
XP_001164543
512
58884
S454
R
I
E
E
E
Q
K
S
K
R
K
G
H
E
Y
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
Q531
K
L
E
V
L
Q
S
Q
K
G
Q
E
S
E
Y
Dog
Lupus familis
XP_534686
571
65327
I514
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
Cat
Felis silvestris
Mouse
Mus musculus
P35235
597
68442
S539
R
I
E
E
E
Q
K
S
K
R
K
G
H
E
Y
Rat
Rattus norvegicus
P41499
597
68440
S539
R
I
E
E
E
Q
K
S
K
R
K
G
H
E
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519242
359
41028
A302
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
F
Chicken
Gallus gallus
Q90687
593
67964
S535
R
I
E
E
E
Q
K
S
K
R
K
G
H
E
Y
Frog
Xenopus laevis
NP_001084076
595
68232
S535
R
I
E
E
E
Q
K
S
K
R
K
G
H
E
Y
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
S659
R
K
R
A
E
E
Q
S
L
Q
V
G
R
E
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
Y476
I
N
T
K
R
A
H
Y
E
V
Q
Q
H
H
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.7
54
95.1
N.A.
99.5
98.9
N.A.
59.2
97.6
93.4
N.A.
N.A.
38.5
N.A.
N.A.
51.9
Protein Similarity:
100
85.7
70
95.1
N.A.
99.8
99.5
N.A.
60.1
98.4
95.8
N.A.
N.A.
51.3
N.A.
N.A.
65.8
P-Site Identity:
100
100
33.3
6.6
N.A.
100
100
N.A.
6.6
100
100
N.A.
N.A.
40
N.A.
N.A.
6.6
P-Site Similarity:
100
100
53.3
20
N.A.
100
100
N.A.
33.3
100
100
N.A.
N.A.
60
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
10
0
10
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
64
55
64
10
0
0
10
0
0
10
0
82
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
10
0
64
0
0
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
64
19
0
% H
% Ile:
10
55
0
0
0
10
0
10
0
10
10
0
0
0
0
% I
% Lys:
10
10
0
10
0
0
55
0
64
0
55
0
0
0
0
% K
% Leu:
0
10
0
0
10
0
0
0
10
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% M
% Asn:
0
10
0
0
0
0
10
0
10
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% P
% Gln:
0
0
0
10
0
64
10
10
0
10
19
10
10
0
0
% Q
% Arg:
64
0
10
0
10
10
0
0
0
55
0
0
10
0
0
% R
% Ser:
0
0
10
0
0
0
10
64
0
0
0
0
10
0
0
% S
% Thr:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
10
% T
% Val:
0
10
0
10
0
0
0
0
0
10
10
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
19
0
0
10
10
0
0
0
0
0
82
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _